Manchester City have had to overcome a real scare against third-division Leyton Orient before a piece of Kevin De Bruyne brilliance helped them advance to the fifth round of the FA Cup.

Orient threatened to pull off a famous upset when they led 1-0 at halftime against Guardiola's four-time defending Premier League champions at Brisbane Road.

But City fought back after the break with goals from substitutes Abdukodir Khusanov and De Bruyne.

"It was impossible to control," Guardiola said. "We played with character, and we are in the next round and it's always nice."

Orient went ahead in spectacular fashion when Jamie Donley's shot from just past the halfway line hit the bar and rebounded off the back of City goalkeeper Stefan Ortega in the 16th minute.

It was officially credited as an own-goal, but Donley took the congratulations as he celebrated wildly in front of the home fans. He was also rewarded with the player-of-the-match award.

But the goal wasn't enough to hold off City's fightback.

Rico Lewis' effort deflected off Khusanov in the 56th to level the match and De Bruyne flicked a shot past Josh Keeley in the 79th to seal victory.

It wasn't all good news for Guardiola, however, with midfielder Nico Gonzalez injured and substituted after 22 minutes of his debut.

Already in the final of the English League Cup, Newcastle advanced in the FA Cup with a hard-fought 3-2 win against Birmingham.

League One leaders Birmingham took the lead inside a minute at St. Andrew's through Ethan Laird. A stunning long-range goal from Birmingham's Tomoki Iwata pulled the game back to 2-2 before halftime.

Newcastle had to wait until the 82nd to regain the advantage when Joe Willock scored his second of the game. Callum Wilson was also on target for the visitors.

Eight-time winners Chelsea were dumped out of the cup by Brighton - losing 2-1 despite going ahead inside five minutes at AMEX Stadium.

Brighton goalkeeper Bart Verbruggen made a mess of Cole Palmer's cross and diverted into his own net to give Chelsea the perfect start.

But the home side powered back, with Georginio Rutter equalising seven minutes later and Kaoru Mitoma firing the winner in the second half.

Flying high in the Premier League, Bournemouth are also through to the fifth round of the cup after a 2-0 victory over Everton.

Antoine Semenyo's penalty and a goal for Daniel Jebbison put Bournemouth on course for the next round by halftime at Goodison Park.

Everton hit the post three times in the second half as David Moyes' team mounted a fightback, but couldn't find a way through.

Ipswich's priority is to avoid relegation from the top flight this season, but a 4-1 win at second-tier Coventry kept their cup run going, with Jack Clarke scoring twice.

Southampton, last in the Premier League, lost 1-0 at home to a Burnley team who are fighting for promotion to the top division.

The latest shutout from Burnley was their 10th in their last 11 games.

Rodrigo Muniz scored both goals for Fulham in a 2-1 win at third-tier Wigan.

The hosts pushed top-flight Fulham, with Jonny Smith levelling the game in the second half before Muniz scored the second of his goals to seal the win.

Leeds, top of the second tier, were knocked out by Millwall - losing 2-0 at home.